Symbol
Name
ID

Hoxa5
homeobox A5
MGI:96177

Phenotype annotations related to respiratory system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

respiratory system phenotype

lung cyst

abnormal alveolar macrophage morphology

lung inflammation

abnormal larynx morphology

abnormal cricoid cartilage morphology

cricoid and tracheal cartilage fusion

abnormal lung development

abnormal branching involved in lung morphogenesis

impaired branching involved in bronchus morphogenesis

impaired branching involved in respiratory bronchiole morphogenesis

impaired lung alveolus development

abnormal lung saccule morphology

abnormal bronchiole epithelium morphology

abnormal bronchus epithelium morphology

increased type II pneumocyte number

abnormal lung weight

abnormal pulmonary acinus morphology

abnormal pulmonary alveolar sac morphology

abnormal pulmonary alveolus morphology

atelectasis

overexpanded pulmonary alveolus

abnormal pulmonary interalveolar septum morphology

thick pulmonary interalveolar septum

emphysema

abnormal pulmonary alveolar parenchyma morphology

abnormal pulmonary elastic fiber morphology

abnormal bronchiole morphology

abnormal respiratory mucosa goblet cell morphology

increased respiratory mucosa goblet cell number

abnormal trachea morphology

abnormal tracheal cartilage morphology

decreased tracheal cartilage ring number

trachea occlusion

trachea stenosis

respiratory distress

abnormal surfactant secretion

decreased surfactant secretion

Availability

Mouse Genotype

Hoxa5^tm1.2Ljea/Hoxa5^tm1.2Ljea

Hoxa5^tm1Ljea/Hoxa5^tm1Ljea

Hoxa5^tm1Rob/Hoxa5^tm1Rob

Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea
Tg(Hoxa5-cre)444CLjea/0 (conditional)

Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea
Tg(Hoxa5-cre)447BLjea/0 (conditional)

Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea
Tg(Sftpc-cre)1Blh/0 (conditional)

Hoxa5^tm1.1Ljea/Hoxa5⁺
Tg(Sftpc-cre)1Blh/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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